Clinical Trial: Bone cancer vaccine now being evaluated

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Clinical Trial: Bone cancer vaccine now being evaluated

Postby spinster » Wed May 21, 2014 10:09 pm

Bone Cancer Vaccine Without Amputation
Meet Denali:10-year-old Italian Spinoni
Clinical Trial: Bone cancer vaccine now being evaluated for dogs with osteosarcoma without amputation

Learn about eligibility and trial details...

Status: This trial is open and enrolling dogs. There are places for 10 dogs diagnosed with early osteosarcoma on this trial.


About This Trial

This new clinical trial uses a novel vaccine for dogs with bone cancer (osteosarcoma). Dr. Mason, an Assistant Professor of Medicine is evaluating the effect of combining a tumor-targeting vaccine with radiation therapy to treat dogs that cannot undergo amputation.

β€œIn the past we have tested this vaccine to determine whether it can prevent spread of osteosarcoma in dogs that had undergone amputation and chemotherapy (the standard of care for dogs with osteosarcoma). The results were encouraging.

"Now we are evaluating whether the same vaccine can be used to treat the primary tumor as well as prevent spread of the disease into the lungs – that is, we are now treating dogs that cannot undergo amputation and follow up chemotherapy.”

The trial is unique – dogs are required to have a biopsy to confirm the diagnosis of osteosarcoma, they receive 2 doses of radiation on 2 consecutive days and are then vaccinated once every 3 weeks for a total of 8 vaccines. There is no chemotherapy in this clinical protocol.

Read more about Denali and the trial at: https://www.vet.upenn.edu/research/cent ... tion-trial
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Re: Clinical Trial: Bone cancer vaccine now being evaluated

Postby SMAbby » Sun Jun 01, 2014 10:22 pm

Thanks for the post!

I have tried to look up info on Ostersarcoma to find out if it is genetic or not. I have found sites that say it is and some that say it is not. Even my vet gave me the answer of "It is not genetic, but it runs in families." HUH? :shock:

it interests me because I know of a dog that died at a very young age with it. This dog had a litter of pups. From this litter of pups a couple of bitch pups were sold to breeders to use as breed stock( I can only assume). SO I am very interested in finding out more about this.

Even if this is not a genetic issue, is it good practice to tempt fate?
VC Max vom Schutzenknapp VJP 75, HZP190, VGP 303 PI 4H Nose, NA 112, UT 204 Invite 196
Baja vom Wamsbach VJP 64, HZP 169, NA 112
Anka vom Loofkamp VJP 66, HZP 139,HZP 172, NA 112
Krystal Creeks Untamed Spirit ( Abby) NA 93 Prize III UT 200 Prize II
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